After a car accident, Peter, Brian, Joe, and Quagmire wake up in a hospital with no memory and discover that they're the last people left on Earth.
After Peter's favorite children's television show gets cancelled, he takes matters into his own hands by creating and starring in his own show for kids. Meanwhile, Meg begins an internship at the hospital with Dr. Hartman.
Stewie meets a little girl who might be his soulmate; Lois buys twin beds after Peter repeatedly crushes her in his sleep.
Stewie and Brian attempt to track down Meg after she's abducted in Paris by sex slave operatives.
Peter joins the Tea Party but doesn't discover until it's too late that Carter Pewterschmidt is using the party to get rid of government for his own selfish motives.