Brian decides to do stand up comedy, but when his set begins to tank, he starts stealing Stewie's Twitter material.
Peter's estranged sister Karen shows up to the Griffin family's Thanksgiving dinner, and Joe, Cleveland, and Quagmire realize that she is the famous wrestler, Heavy Flo.
After hearing that Stewie has been having nightmares, Brian decides to help. He tries to cure Stewie by making a list of Stewie's fears and using exposure therapy to deal with them.
When the successful family of Lois' ex-boyfriend, Ross Fishman, mentions that they're all climbing Mount Everest, Peter announces that the Griffins are climbing it too...and will beat the Fishmans to the top. But the Griffins are woefully unprepared for the trip.
The Griffins are chosen to be a Neilsen family, and Peter takes advantage of the chance to reformat TV to his taste - except that everyone else hates his changes.
Brian overhears a doctor telling Carter that Carter has only two weeks to live, but when Lois frantically checks on her father he's mysteriously healthy - and Brian wants to know why.
As Christmas approaches...Peter tells the story of the Nativity, with friends and family members appearing as biblical characters.
After Peter's favorite children's television show gets cancelled, he takes matters into his own hands by creating and starring in his own show for kids. Meanwhile, Meg begins an internship at the hospital with Dr. Hartman.
Stewie and Brian attempt to track down Meg after she's abducted in Paris by sex slave operatives.
Peter joins the Tea Party but doesn't discover until it's too late that Carter Pewterschmidt is using the party to get rid of government for his own selfish motives.
Three skits: the British program that Family Guy is based on, everybody Peter touches turns into Robin Williams, and a look at the day through Stewie's eyes.
Peter talks Joe into having an affair and gets into another epic fight with the giant chicken.