Isagi Yoichi is invited to Blue Lock, which seeks to train and pick the best striker out of 300 high-school forwards who can win Japan the World Cup.
The top five players in Blue Lock will play as forwards in the U-20 Cup. Those who drop out will lose the chance to play for the Japanese team.
The first selection is the round-robin tournament of five teams. But due to a special rule, the matches turn into chaotic scrambling for the ball.
Responding to Ego's urge to "take up a weapon," the players discuss what their weapons are for the matches. Isagi struggles to identify what it is.
Relying on his raw instinct of "the smell of the goal," Isagi battles Team Y's playmaker, Niko Ikki, as they "read" each other's hand on the field.
The next match is against Team W, led by the Wanima twins. Their eye contact and impeccable combinations are hard to beat.
Team Z faces an opponent who knows everything about their weapons. But they don't give up the fight, and Isagi continues to believe in himself.
Needing to win against the strongest team in the group, Isagi goes to meet with a certain someone to attain the secret formula for scoring goals.
About to give up against Team V, Bachira Meguru's play sets fire on the ego in Team Z's hearts. The awakening of the diamonds in the rough has begun.
Team Z have the momentum of the game. But Team V's monster, Nagi, has "awakened." In the chain reaction to awakening, Isagi learns to use his weapon.
Isagi finds the final piece of the puzzle that's necessary for his evolution. The first selection of Blue Lock, where ego comes head-to-head, ends.
In Blue Lock's second selection, a teammate becomes a foe, and a foe becomes a teammate. Isagi meets Itoshi Rin, the strongest egoist he's ever met.
In the Rivalry Battle, the winner takes a player from the losers. Isagi's team faces the team of the top three players in the New Blue Lock ranking.
Facing the team of Baro and Naruhaya, where losing means disqualification, Isagi and Nagi think hard on their individual strengths to win the match.
Isagi struggles against Baro and Naruhaya but finds a glimpse of his new weapon. As the egos of everyone collide, it is time for Isagi to evolve.
Isagi struggles to figure out a coherent strategy that plays to his and his team's strengths before their next opponents, who are all familiar faces.
Through observing and analyzing his opponents, Isagi discovers a new way to use his weapon and evolve himself one step further.
Baro, the king of the field, is left out of the chain of evolution because of his strong ego. When Isagi overtakes him, defeat makes Baro kneel down.
To cause more chemical reactions in the next stage, Isagi's team pick one player from the other team, who showed ego to devour them during the game.
Isagi and others are set to play a revenge match against the "Top 3," who have defeated them. They're ready to throw everything they have at them.
Isagi and Nagi's combination bursts and play light up the fire in Rin. Rin's dominating play gradually corners Isagi's team once again.
The game has entered its final phase, going through a seesaw struggle. Isagi continues to be awakened, and Bachira faces his own ego.
Bachira awakens his ego and forges on for his goal. At the end of the play is Isagi, who's waiting for him because he believes in Bachira's ego.
Next for Isagi's team is a match against world-level star players. Blue Lock project, created to produce the world's best striker, enters a new phase.
