After Brian gets diagnosed with liver disease from his heavy drinking, Peter is stuck with the task of inserting Brian's suppository pills. When Brian bites Peter's arm in self-defense, Brian becomes the alpha dog.
While watching a celebrity roast with Brian, Peter is inspired to throw a roast for himself, but it backfires when his friends go further then he expected. Hurt by what was said, Peter decides to seek out a new group of friends.
When Liam Nesson comes to town to shoot a movie, Peter is convinced that he can beat him up. Unsuccessful, Peter winds up in jail but is bailed out by Liam Neeson and becomes his manservant.
Peter and the guys are invited on a Bahamas couples' vacation with their wives. Upon arrival, their host reveals that they're at a "couples' counseling retreat."
After Quagmire shows off his cooking skills to the gang, Lois suggests that he audtion for Channel 5's new cooking show.