The Griffins take Stewie to the hospital, fearing his arm may be broken. Dr. Hartman informs them that Stewie still hasn't had his vaccinations.
Carter purchases Pawtucket Brewery and becomes Peter's new boss. With great pleasure, he forces Peter to assume a variety of humiliating roles. Peter overhears Carter order staff to illegally make beer cans out of dangerous and cheap materials.
Chris decides to run for homecoming king and, to the surprise of everyone, wins! Lois, Brian, and Stewie fear that Chris's classmates only voted for him in order to pull a prank on him at the dance.
Brian calls tech support for his computer and quickly hits it off with Padma, the female tech support operator from India. Brian flies to India to meet her with Stewie tagging along.
After hearing that Stewie has been having nightmares, Brian decides to help. He tries to cure Stewie by making a list of Stewie's fears and using exposure therapy to deal with them.
The Griffin's are forced to flee their hometown of Quahog after Peter's offensive newspaper comics spark uproar amongst the local townspeople. Driving through the night, the Griffin's arrive in a small suburban town called "Springfield".
Peter and Lois receive a note from Principal Shepherd pinned to Chris' backpack. During their meeting they learn that if Chris doesn't pass his upcoming history exam he will have to repeat the 9th grade.
Meg is worried that she won't do well on her SATs, so she convinces Brian to take the test for her. A confident Brian agrees to the challenge, and even dresses up like Meg, only to find out that he received the lowest score in the class.
At Stewie's graduation, Brian states that Stewie's proud moment is no big feat. Stewie takes it upon himself to try and acquire some real world knowledge. Meg is discovered by a photographer who asks her if she would like to model for him.
When Stewie complains that his tricycle has been stolen, Peter and his friends are spurred into action. Peter finds the kid responsible, and the success leads the group to start a detective agency for kids.
After Cleveland diffuses an argument between Quagmire and Joe, Peter encourages him to open his own therapy office. Meanwhile, Meg gets a job as a TSA agent, and revels in the positive attention she gets for being the "office hottie".
After Brian gets diagnosed with liver disease from his heavy drinking, Peter is stuck with the task of inserting Brian's suppository pills. When Brian bites Peter's arm in self-defense, Brian becomes the alpha dog.
While watching a celebrity roast with Brian, Peter is inspired to throw a roast for himself, but it backfires when his friends go further then he expected. Hurt by what was said, Peter decides to seek out a new group of friends.