As Mista closes in on Sale, all signs seem to point to an easy kill.
Amid the gritty beauty of Napoli, the Joestar lineage lives on. After sidestepping long-term Joestar ally Koichi Hirose, Giorno must contend with two powerful Mafia gangsters, Leaky Eye Lucca and the enigmatic Bruno Bucciarati.
Eager to identify Leaky Eye Luca's attacker, Bucciarati confronts Giorno and unleashes a Stand attack to dismantle him piece by piece. But Giorno counters with his Stand Golden Wind, surprising not just his adversary, but also himself.
Determined to join the mafia gang Passione, altruistic Giorno is introduced by Bucciarati to the grotesquely corpulent Polpo, an incarcerated capo who tests Giorno's loyalty with a simple but bizarrely lethal test.
Plodding amid the dusky shadows of a peaceful piazza is Polpo's macabre Stand, which assails any who dare witness the reigniting of the lighter. Giorno deciphers its method of attack, but is soon staring death in the face.
While word of the high-ranking capo Polpo's alleged suicide sparks astonishment and speculation in the crime syndicate Passione, Giorno is inducted into Bucciarati's eclectic mafia family.
Sailing to the Isle of Capri to recover Polpo's estate, Bucciarati and team are ambushed by a stealthy enemy Stand that deflates them into rubber-like human pelts.
Having beheaded their captor by zipper, the team learns its plan has been leaked to Zucchero's cohort, who is lying in wait on Capri. With fish and gun, Giorno and Mista swim to beat the boat and weed out their assassin-in-waiting.
Within arm's reach of Polpo's fortune, Bucciarati and team meet the unassuming Pericolo, a capo who has come to accept the treasure.
After an encounter with the Hitman Team's Formaggio, Narancia hunts down his assailant with a hail of bullets as Formaggio tries to understand his attacker's tracking skills.
Narancia is unshakable as he uses firepower and CO2 detection to survive Formaggio's body-shrinking attack.
Giorno, Abbacchio and Fugo travel to Pompeii to find a hidden key pivotal in their protection of Trish. Facing the trio, however, is more than the lonely remains of ancient Roman villas and colonnades.
Illuso has pulled Fugo into his mirror world as Abbacchio rushes to retrieve the key, despite Giorno's stern advice. But Abbacchio cannot escape a similar fate, leaving him and later Giorno to resort to self-mutilation.
Ready to escort Trish by train, the gang finds on the platform a lone turtle lingering by the drinking fountain, just as the boss instructed.
Bucciarati and gang hide inside a turtle aboard their train hurtling toward Florence as Mista fights to keep Pesci's body-piercing fish hook from ensnaring his brain. Meanwhile, Prosciuttohas released his Stand.
To save his squad, Bucciarati risks all by grabbing hold of Prosciutto and hurling himself off the speeding train, only to be saved by Pesci's hook.
Bucciarati and crew head to Venice by car after a near-death encounter with Pesci. Unbeknownst to them, Melone from the Hitma Team has created an atomizing ancillary Stand from Bruno's blood and the body of an unsuspecting female.
Giorno fights transmutation with transmutation as he weaponizes his own severed hand and imbues inanimate objects with life against Melone's baby Stand.
Ghiaccio's Stand, White Ice is able to envelop him like a bodysuit and able to freeze everything around him to extremely low temperatures. Giorno and Mista somewhat make it to Venice, despite being partially frozen by Ghiaccio.
In the crypt of a Venetian church, Bruno discovers not only the brutal truth behind the Boss's true intentions but also the unstoppable Stand power he wields, a power that leaves Bruno in a pool of blood and in a moral quandary.
Bruno and team, learn from Trish during a moment of calm at a Venetian café a trip to Sardegna is vital. Chaos, then, erupts as Narancia loses his tongue and ability to speak the truth after spotting a shark in his soup.
As Giorno is teleported between puddles with Squalo's shark attached firmly to his jugular, Narancia tries to sniff out the perpetrator using his CO2 tracer but is inhibited by Tiziano's tongue-fusing Stand.
Bruno et al head to Marco Polo airport to venture to Sardegna to discover the truth behind Trish's father.
At cruising altitude, Trish faces a voracious and fleshy mass of a Stand that strikes at the slightest movement. Meanwhile, Giorno's pulsating broach, the key to the team's survival, lies waiting—as does an unseen force within Trish.
Bruno and team make an emergency landing in Sardegna where the Hitman Team leader, Risotto, is also determined to uncover a certain mystery. Doppio, the result of a seemingly impossible pregnancy, has his own goals on the island.
Having discovered there is more to skittish Doppio than meets the eye, Risotto uses his Stand to manifest various metallic instruments of torture from within his enemy.
A picturesque Sardinian cliff becomes the bloody backdrop to Doppio's sudden dominance over Risotto, courtesy of Narancia's own Stand. Abbacchio works to rewind time 15 years to identify the identity of a certain photographer.
With Abbacchio's replaying ability interminably stamped in stone, Bruno and team analyze the cryptic face and fingerprints left behind when a mysterious call arrives. They must race to the Colosseum if they hope to ever defeat the Boss.
No sooner than Bruno and team set foot on the shore near Rome the team finds a flesh-eating mold devouring everyone in sight. It's the work of Cioccolata, made worse by his partner Secco.
Branching off from Bruno, who opts to tackle the underground swimmer Secco, Giorno and Mista chase Cioccolata as he flies to spread rotten ruin upon Rome. Their battles unfold in front of a mystery ally.
One fierce battle ends in Cioccolata's defeat, but another unfolds after Secco listens to Cioccolata's final voicemail. Bucciarati sinks into an intense underground struggle to stop Secco from reaching the secret stationed at the Colosseum.
The curtains are down on his skirmish with Secco, but Bucciarati must race against time to reach the Colosseum as he realizes his body is nearing the end of the line.
Key to defeating the Boss in hand, Polnareff waits for Bucciarati and crew. But the one who appears before him first is none other than the Boss of the Passione himself, Diavolo.
Silver Chariot transforms into Chariot Requiem, its new power swapping the souls of all living creatures nearby. Realizing the dangers of the arrow in the wrong hands, Giorno and crew scramble to get ahold of it before Diavolo does.
Grotesque disfigurations begin to emerge from the soul-swapped bodies as Chariot Requiem's frenzy rages on. Bucciarati and crew need to take back the arrow, and fast. Giorno has a terrifying revelation, stopping everyone in their tracks.
Solving the mystery of Requiem, Diavolo takes control of Trish's soul and steals the arrow. Attacks do nothing against Emperor Crimson's time leaps and Eulogy's predictions. Just as Diavolo is about to pierce his own Stand with the arrow.
Righteous actions born of truth shall never be destroyed. Piercing Golden Wind with the arrow, Giorno draws the final battle against Diavolo to a close. Diavolo, robbed of the mercy of death, spirals violently into an end that never ends.
Bucciarati and gang help a local florist chisel out the truth behind his daughter's apparent suicide. Mista is assigned to track down her lover, whose ties with destiny had unwittingly cast a light upon Bucciarati's fate.