Dr. Venture's new experiment has the entire family interested--not to mention trapped inside! The Ventures' strange new neighbor, master of mysticism Dr. Orpheus, may be the only one who can help them escape. Meanwhile Dean falls for Dr. Orpheus's teenaged daughter and Brock falls for his old flame: Molotov Cocktease.
On a scientific expedition in the Bermuda Triangle, Doc's experimental equipment awakens and possibly enrages the submerged ghost of Major Tom, a test pilot who crashed in an experimental aircraft designed by Doc's father. While there, the Ventures' hydrofoil is hijacked by a group of fake ghost pirates who've been stranded in the sargassum since Jesus Jones was popular.
Dr. Venture, Pete White and Master Billy Quizboy are invited to take part in a top secret government think tank.
The Monarch sends Dr. Girlfriend undercover to seduce Dr. Venture in order to inject him with a body-altering serum. Meanwhile, Brock is deeply depressed to he learn his secret agent license to kill has expired, but the boys are hell-bent on helping him cram for his government exam.
The Monarch finally has the Venture family right where he wants them--hanging upside down above the Amazon river! But his victory is postponed when Dean suffers a strange but fairly common injury--acute testicular tortion. According to the bi-laws of the Guild of Calamitous Intent, a temporary truce must be called in order to get Dean medical attention, so Brock and Hank are held as collateral.
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