Mauro Brozzi, a popular footballer, asks Lupin for help to steal a medical record from a dangerous criminal's well patrolled mansion that proves he's using doping in order to fight off his upcoming blindness.
Lupin announces that he'll manage to steal a precious diamond from the Prince of England, who is currently in Italy to pay a visit to Rebecca. However, Lupin is forced to fight for his prize against Nyx, a well trained member of the MI6.
Jigen finds himself in a town where a dangerous boss, Eric, punishes anyone holding a firearm by wounding them so severely that they'll die an agonizing death.
Fujiko seems to fall in love with Luca, a young circus performer. But the truth is that Fujiko is simply pretending in order to lure him into revealing her all the magic tricks that he has learned from his recently deceased mentor.
Rebecca invites Lupin to one of her mansions, near Venice, in order to sign the papers for their divorce when a horde of zombies suddenly attack the islands.
Zenigata is assigned to protect Elena Gotti, the famous wife of a recently deceased billionaire, Roberto Gotti. In fact it's said that she's the only one to know where Roberto hid all his money, so her life is threatened by many robbers.
Brigitte, Nyx's daughter (who, like her sisters and her mother, doesn't know about his father's true job), is kidnapped during a school trip by women's smugglers that want to sell her as a prostitute to her own father.
Lupin and Jigen go looking for a treasure in an old castle which is said to be haunted by a ghost. Here, Lupin must face an aged woman thief and her two sons, but is helped by a little girl, Carla, who claims to be the owner's daughter.
Sometime ago Goemon had been hired with other killers by the young Italian politician Leopoldo Flago in order to kill Samuel Decale, an African dictator, and his bodyguard, Zora, a legendary sniper.
Lupin is invited by both Fujiko and Rebecca to a party where the collection of a recently deceased famous wine collector will be put on sale and decides to accept both the invites trying to jump from one girl to the other during the party.
Rebecca is kidnapped by the MI6 and Robson calls for Lupin's help. Lupin finds out that the MI6 is looking for the research of Rebecca's lost love, Wataru, a young Japanese scientist who died sometime ago.
Lupin manages to decrypt Wataru's notes finding himself in a sort of dream where he meets Wataru himself. He informs Lupin that this world has the power to influence all mankind and that someone killed him in order to find out his secrets.
Zenigata is able to stop several attempts by Lupin to escape from many Italian prisons, but the government can't afford such surveillance. So, to prevent him from escaping, Zenigata escorts Lupin to an impenetrable cell on a tiny island.
Lupin is out of money, so he decides to steal the Mona Lisa in order to sell it. He completes his theft, but soon finds out it's a fake, since the original Mona Lisa is in the hands of a corrupt politician using it to fund his political career.