Peter's estranged sister Karen shows up to the Griffin family's Thanksgiving dinner, and Joe, Cleveland, and Quagmire realize that she is the famous wrestler, Heavy Flo.
With Lois and her mother Babs out at the spa, Peter is forced to spend the afternoon her father, Carter. The two are quickly sucked into a "promising" online deal involving loaning a large sum of money to a Nigerian prince.
After hearing that Stewie has been having nightmares, Brian decides to help. He tries to cure Stewie by making a list of Stewie's fears and using exposure therapy to deal with them.
After an unfortunate unicyle accident at Meg's 17th birthday party, Peter tumbles down the stairs and into his father, Francis. On Francis' deathbed, he leaves his son with the unsettling parting words "You're a fat stinking drunk." During hypnotherapy, Peter remembers a time where Francis told him that he was not his real father. Peter then goes on a journey to find his real dad.
Chris falls for his new substitute teacher (who wants him to kill her husband), while Brian tries to get through to a bunch of school rejects.
A mall makeover launches Meg into super-stardom, culminating in an appearance on Saturday Night Live.
When Peter is diagnosed as mentally retarded, he realizes the many and mischievous uses to which he could apply his newfound handicap.
Brian and Quagmire vie for the same woman's affections when they are cast on "The Bachelorette".
Peter racks up a huge tab at Mort's pharmacy and, unable to pay it back, offers to give Meg to Mort's son, Neil, as payment. Meanwhile, Stewie develops a crush on his college-aged babysitter, but when she doesn't return his affections, he becomes vengeful.
When the Griffins take a trip to Lois' childhood home, Lois decides to finally pursue her childhood dream of becoming a model. Local celebrity soon turns to national renown and when Lois gets caught up in a whirlwind of diet pills and partying, Peter has to recruit Carter's help to bring her back to reality.
When Brian starts spending more time with his new girlfriend, Peter gets jealous. And when they try to get James Woods High renamed Peter gets mad and calls in the real James Woods, who comes to town, ensuring the school's name stays the same. Peter and James Woods form a great friendship, but when Peter starts to miss Brian, James Woods gets jealous and things take a dark turn.